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This study shows that, on infection by pathogenic bacterium\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    , Toll-like receptor (TLR) pathways suppress type I IFN gene induction that is mediated by stimulator of IFN genes. Type I IFNs are critical for antiviral immunity but detrimental to macrophage bactericidal activity. The TLR pathways selectively suppress IFN regulatory factor 3, an essential transcription factor for type I IFN gene induction, through induction\/activation of mitogen-activated protein kinase phosphatases, revealing a unique mechanism of beneficial innate signaling interference against bacterial infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1320145110","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:49:39Z","timestamp":1384818579000},"page":"19884-19889","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor\u2013mediated enhancement of the MKP-IRF3 axis"],"prefix":"10.1073","volume":"110","author":[{"given":"Hideo","family":"Negishi","sequence":"first","affiliation":[{"name":"Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo 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