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By using a genetic approach, our study clearly demonstrates that mTORC1, but not mTORC2, is essential for cell cycling of early T-cell progenitors. More importantly, we reveal that loss of mTORC1 efficiently eradicates T-cell acute lymphoblastic leukemia cells, but not myeloid leukemia. Thus, understanding the cell-context\u2013dependent role of mTOR illustrates the potential importance of mTOR signals as therapeutic targets.<\/jats:p>","DOI":"10.1073\/pnas.1320265111","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T21:44:15Z","timestamp":1393278255000},"page":"3805-3810","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells"],"prefix":"10.1073","volume":"111","author":[{"given":"Takayuki","family":"Hoshii","sequence":"first","affiliation":[{"name":"Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, 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