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Our findings reveal a previously unidentified link between Erbin and ERK signaling in the heart and implicate Erbin in the development of cardiac hypertrophy and heart failure. Erbin is particularly interesting due to its well-established interaction with the ErBb2\/Her2 receptor. Clinical studies have observed cardiotoxicity associated with Herceptin therapy, reflecting the crucial role of Her2-mediated signaling in cardiac homeostasis. In this study, we describe a cardioprotective role for Erbin, which suggests it is a potential target for cardiac gene therapy.<\/jats:p>","DOI":"10.1073\/pnas.1320350111","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:10:32Z","timestamp":1396915832000},"page":"5902-5907","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["Erbin is a negative modulator of cardiac hypertrophy"],"prefix":"10.1073","volume":"111","author":[{"given":"Inbal","family":"Rachmin","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel\u2013Canada, Hebrew University Medical School, Jerusalem 91120, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagi","family":"Tshori","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine 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