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We demonstrate that infertility in\n                    <jats:italic>SVS2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    male mice is caused not only by failed copulatory plug formation but also by the disruption of ejaculated sperm in the uterus by uterus-derived cytotoxic factors. SVS2 acts to protect sperm against these uterus-derived cytotoxic factors by coating the sperm surface and preventing uterine attack. Thus, our results provide evidence that mammalian males have developed a protective strategy against female attack at the gamete level.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1320715111","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T21:26:27Z","timestamp":1393881987000},"page":"4145-4150","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":119,"title":["Seminal vesicle protein SVS2 is required for sperm survival in the uterus"],"prefix":"10.1073","volume":"111","author":[{"given":"Natsuko","family":"Kawano","sequence":"first","affiliation":[{"name":"Department of Reproductive Biology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Araki","sequence":"additional","affiliation":[{"name":"Misaki Marine Biological Station, Graduate School of Science, University of Tokyo, Miura, Kanagawa 238-0225, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Center, Toin University of Yokohama, Yokohama 225-8502, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Hibino","sequence":"additional","affiliation":[{"name":"Faculty of Education, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Ohnami","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maako","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Hasuwa","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Misaki Marine Biological Station, Graduate School of Science, University of Tokyo, Miura, Kanagawa 238-0225, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Miyado","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"crossref","unstructured":"Suarez SS (2006) in Knobil and Neill\u2019s Physiology of Reproduction ed Neill JD (Academic New York) 3rd Ed pp 113\u2013145.","DOI":"10.1016\/B978-012515400-0\/50008-7"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/179258a0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1962.202.1.179"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0720373"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.044644"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.110.085100"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059042"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi047"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305609111"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.056887"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.069054"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81073-9"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003185"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.59.105"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod43.1.55"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.12867"},{"key":"e_1_3_3_17_2","first-page":"4985","article-title":"Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1","volume":"125","author":"Satouh Y","year":"2012","unstructured":"Y Satouh, N Inoue, M Ikawa, M Okabe, Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1. 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