{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:04:29Z","timestamp":1792710269415,"version":"4.5.0"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"52","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,12,24]]},"abstract":"Significance<\/jats:title>\n Cellular interactions that regulate the immune response of T cells to viral infection are poorly understood. Here we report that in the absence of activity of CD8 regulatory T-cells (CD8 Treg cells), antiviral immunity is enhanced and the deleterious effects of viral infection are constrained. Using a genetically modified mouse model that displays defective regulatory activity of CD8 Treg cells, the immune response against viruses was substantially enhanced during the acute and chronic phase of viral infection; this enhanced antiviral response prevented tissue damage associated with viral infection. This suggests that protective immunity to viral infection can be achieved by blocking the inhibitory effects of CD8 Treg cells and opens the possibility of unique approaches to treat viral infection.<\/jats:p>","DOI":"10.1073\/pnas.1320999110","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:11:29Z","timestamp":1386634289000},"page":"21089-21094","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Genetic disruption of CD8\n +<\/sup>\n Treg activity enhances the immune response to viral infection"],"prefix":"10.1073","volume":"110","author":[{"given":"Tobias A. W.","family":"Holderried","sequence":"first","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02215;"},{"name":"Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02215; and"},{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, University of D\u00fcsseldorf, 40025 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, University of D\u00fcsseldorf, 40025 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02215;"},{"name":"Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02215; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Cantor","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02215;"},{"name":"Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02215; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3251"},{"key":"e_1_3_3_2_2","volume-title":"On the Origin of the Vaccine Inoculation","author":"Jenner E","year":"1801","unstructured":"E Jenner On the Origin of the Vaccine Inoculation (Shury, London, UK, 1801)."},{"key":"e_1_3_3_3_2","first-page":"363","article-title":"Some unmet challenges in the immunology of viral infections","volume":"10","author":"Rouse BT","year":"2010","unstructured":"BT Rouse, AE Lukacher, Some unmet challenges in the immunology of viral infections. Discov Med 10, 363\u2013370 (2010).","journal-title":"Discov Med"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-100001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-012-0146-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4112650"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2307\/4581290"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60197-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1780"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.4.1043"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/362758a0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132723"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100213108"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155209"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003362"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018974108"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09370"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810383105"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.017"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp107"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/342559a0"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.7.4123"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4924"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01152"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5444"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.07.017"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10624"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118834109"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118842"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2606"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.11.016"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00090"},{"key":"e_1_3_3_34_2","doi-asserted-by":"crossref","unstructured":"von Herrath M Whitton JL (2001) Animal models using lymphocytic choriomeningitis virus. Curr Protocols Immunol 36:19.10.1\u201319.10.19.","DOI":"10.1002\/0471142735.im1910s36"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.01.005"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.521"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1320999110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:17:39Z","timestamp":1649805459000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1320999110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,9]]},"references-count":36,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2013,12,24]]}},"alternative-id":["10.1073\/pnas.1320999110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1320999110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,9]]},"assertion":[{"value":"2013-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}