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Using a single-molecule tracking technique on two transmembrane proteins that bend the membrane differently and are reconstituted in giant unilamellar vesicles, we show that the mobility of a membrane protein is crucially dependent on the local membrane deformation self-generated around the protein, which can be tuned by adjusting membrane tension. The feedback between membrane shaping and mobility is well explained by analytical and numerical models that include the friction of the deformed membrane patch with the surrounding medium and the friction internal to the bilayer.<\/jats:p>","DOI":"10.1073\/pnas.1321054111","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T01:25:24Z","timestamp":1395710724000},"page":"5083-5087","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["Shape matters in protein mobility within membranes"],"prefix":"10.1073","volume":"111","author":[{"given":"Fran\u00e7ois","family":"Quemeneur","sequence":"first","affiliation":[{"name":"Institut Curie, Centre de Recherche, F-75248 Paris, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 168, F-75248 Paris, France;"},{"name":"Universit\u00e9 Pierre et Marie Curie, F-75252 Paris, France;"},{"name":"CelTisPhyBio Laboratory of Excellence and Paris Sciences et Lettres, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon K.","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of California, Santa Barbara, CA 93106;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Renner","sequence":"additional","affiliation":[{"name":"Biologie Cellulaire de la Synapse, Institut de Biologie Ecole Normale Sup\u00e9rieure, F-75005 Paris, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1024, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Atzberger","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of California, Santa Barbara, CA 93106;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Bassereau","sequence":"additional","affiliation":[{"name":"Institut Curie, Centre de Recherche, F-75248 Paris, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 168, F-75248 Paris, France;"},{"name":"Universit\u00e9 Pierre et Marie Curie, F-75252 Paris, France;"},{"name":"CelTisPhyBio Laboratory of Excellence and Paris Sciences et Lettres, F-75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lacoste","sequence":"additional","affiliation":[{"name":"CelTisPhyBio Laboratory of Excellence and Paris Sciences et Lettres, F-75005 Paris, France;"},{"name":"Laboratoire de Physico-Chimie Th\u00e9orique, Ecole Sup\u00e9rieure de Physique et Chimie Industrielles, F-75231 Paris, France; and"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7083, F-75231 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"5","article-title":"Mouvement brownien et r\u00e9alit\u00e9 mol\u00e9culaire","volume":"19","author":"Perrin JB","year":"1909","unstructured":"JB Perrin, Mouvement brownien et r\u00e9alit\u00e9 mol\u00e9culaire. 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