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Modeling of BCR-ABL1 in complex with ponatinib, a potent pan-BCR-ABL1 TKI, highlighted the presence of complex BCR-ABL1 mutant proteins capable of escaping all available TKI therapy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1321173111","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T20:52:24Z","timestamp":1392756744000},"page":"3550-3555","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy"],"prefix":"10.1073","volume":"111","author":[{"given":"Don L.","family":"Gibbons","sequence":"first","affiliation":[{"name":"Department of Thoracic, Head\/Neck Medical Oncology and Department of Molecular and Cellular Oncology, MD Anderson Cancer Center, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Pricl","sequence":"additional","affiliation":[{"name":"Molecular Simulation Engineering Laboratory, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Posocco","sequence":"additional","affiliation":[{"name":"Molecular Simulation Engineering Laboratory, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Laurini","sequence":"additional","affiliation":[{"name":"Molecular Simulation Engineering Laboratory, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Fermeglia","sequence":"additional","affiliation":[{"name":"Molecular Simulation Engineering Laboratory, Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanshi","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, University of Michigan, Ann Arbor, MI 48109; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Talpaz","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, University of Michigan, Ann Arbor, MI 48109; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Donato","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, University of Michigan, Ann Arbor, MI 48109; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Quint\u00e1s-Cardama","sequence":"additional","affiliation":[{"name":"Department of Leukemia, MD Anderson Cancer Center, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0596-561"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Deininger M et al. 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