{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:06:01Z","timestamp":1792001161209,"version":"4.4.0"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,1,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    We obtained evidence that the rapid turnover of Mcl1 has physiological significance by analyzing mice bearing a modified allele of\n                    <jats:italic>Mcl1<\/jats:italic>\n                    that proved to encode a stabilized form of Mcl1. In cells under stresses such as protein synthesis inhibition or UV radiation, its life span was much longer than WT Mcl1. Male mice bearing only the modified allele were sterile due to excess early spermatogenesis, and the modified allele ameliorated the polycystic kidney disease arising in mice lacking prosurvival Bcl2. Notably, the\n                    <jats:italic>Mcl1<\/jats:italic>\n                    allele accelerated Myc-induced acute myeloid leukemia. Thus, under certain circumstances, the Mcl1 N terminus regulates its degradation, certain cell types require Mcl1 degradation to induce apoptosis, and Mcl1 turnover serves as a tumor-suppressive mechanism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1321259110","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T01:33:33Z","timestamp":1387589613000},"page":"261-266","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":46,"title":["Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis"],"prefix":"10.1073","volume":"111","author":[{"given":"Toru","family":"Okamoto","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Coultas","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Metcalf","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F.","family":"van Delft","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Glaser","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Strasser","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bouillet","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry M.","family":"Adams","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; and"},{"name":"Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C. 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