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In this paper, a gonadotrope-specific sorting determinant on LH has been identified, and FSH was diverted into the LH secretory pathway in vivo. FSH released like LH from pituitary dramatically enhanced the ovarian responses. Our studies provide a molecular basis for the evolution of distinct patterns of gonadotropin secretion and explain the origin of estrus cycles in mammals.<\/jats:p>","DOI":"10.1073\/pnas.1321404111","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T02:13:03Z","timestamp":1396318383000},"page":"5735-5740","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice"],"prefix":"10.1073","volume":"111","author":[{"given":"Huizhen","family":"Wang","sequence":"first","affiliation":[{"name":"Departments of aMolecular and Integrative Physiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Larson","sequence":"additional","affiliation":[{"name":"Departments of aMolecular and Integrative Physiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Jablonka-Shariff","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Pearl","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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