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The rates of synthesis of the individual MHC peptides and their source proteins were followed using stable isotope labeling and quantitative proteomics and peptidomics analyses. We conclude that DRiPs are a significant source of MHC peptides. Many of these DRiPs are misassembled surplus subunits of protein complexes and therefore are degraded soon after synthesis.<\/jats:p>","DOI":"10.1073\/pnas.1321902111","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T02:59:49Z","timestamp":1397012389000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":101,"title":["The nature and extent of contributions by defective ribosome products to the HLA peptidome"],"prefix":"10.1073","volume":"111","author":[{"given":"Dmitry","family":"Bourdetsky","sequence":"first","affiliation":[{"name":"Department of Biology, Technion\u2013Israel Institute of Technology, Haifa 32000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E. 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