{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:11:00Z","timestamp":1791112260362,"version":"4.1.0"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,6,25]]},"abstract":"<jats:p>\n                    Interneurons are critical for shaping neuronal circuit activity in many parts of the central nervous system. To study interneuron function in the basal ganglia, we tested and characterized an NK-1 receptor-based method for targeted ablation of specific classes of interneuron in the striatum. Our findings demonstrate that the neurotoxin SP-PE35, a substance P\u2013\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    exotoxin conjugate, selectively targets striatal cholinergic and nitric oxide synthase\/somatostatinergic interneurons when injected locally into the striatum. The effects of this selective cell targeting encompassed alterations in both behavioral and neural responses to dopaminergic stimulation, including altered patterns of early-gene response in striosomes and matrix. We conclude that NK-1-bearing local circuit neurons of the striatum regulate the differential responses of striatal projection neurons to dopamine-mediated signaling.\n                  <\/jats:p>","DOI":"10.1073\/pnas.132212499","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:46:49Z","timestamp":1027680409000},"page":"9004-9009","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":84,"title":["Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation"],"prefix":"10.1073","volume":"99","author":[{"given":"E.","family":"Saka","sequence":"first","affiliation":[{"name":"Department of Brain and Cognitive Sciences and The McGovern Institute for Brain Research, Massachusetts Institute of Technology, E25-618, 45 Carleton Street, Cambridge, MA 02139; Neural Gene Expression Unit, National Institutes of Health, Pain and Neurosensory Mechanisms Branch, Building 49, Room 1A08, 49 Convent Drive, MSC-4410, Bethesda, MD 20892-4410; and Biotherapy Section, Laboratory of Molecular Biology, National Cancer Institute, Building 37, Room 5124, 37 Convent Drive, MSC-4264, Bethesda,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Iadarola","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences and The McGovern Institute for Brain Research, Massachusetts Institute of Technology, E25-618, 45 Carleton Street, Cambridge, MA 02139; Neural Gene Expression Unit, National Institutes of Health, Pain and Neurosensory Mechanisms Branch, Building 49, Room 1A08, 49 Convent Drive, MSC-4410, Bethesda, MD 20892-4410; and Biotherapy Section, Laboratory of Molecular Biology, National Cancer Institute, Building 37, Room 5124, 37 Convent Drive, MSC-4264, Bethesda,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences and The McGovern Institute for Brain Research, Massachusetts Institute of Technology, E25-618, 45 Carleton Street, Cambridge, MA 02139; Neural Gene Expression Unit, National Institutes of Health, Pain and Neurosensory Mechanisms Branch, Building 49, Room 1A08, 49 Convent Drive, MSC-4410, Bethesda, MD 20892-4410; and Biotherapy Section, Laboratory of Molecular Biology, National Cancer Institute, Building 37, Room 5124, 37 Convent Drive, MSC-4264, Bethesda,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Graybiel","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences and The McGovern Institute for Brain Research, Massachusetts Institute of Technology, E25-618, 45 Carleton Street, Cambridge, MA 02139; Neural Gene Expression Unit, National Institutes of Health, Pain and Neurosensory Mechanisms Branch, Building 49, Room 1A08, 49 Convent Drive, MSC-4410, Bethesda, MD 20892-4410; and Biotherapy Section, Laboratory of Molecular Biology, National Cancer Institute, Building 37, Room 5124, 37 Convent Drive, MSC-4264, Bethesda,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,6,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90104-I"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970721)384:1<1::AID-CNE1>3.0.CO;2-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91658-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90355-C"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-02-00599.1994"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-09-05999.1995"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6486"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/73949"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00305.2002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)98374-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00155-X"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00039-4"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091209"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00018-1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902430304"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/323625a0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903320409"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000306)418:2<156::AID-CNE3>3.0.CO;2-Z"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-927"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1065"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80288-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248361"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199907)33:1<26::AID-SYN3>3.0.CO;2-4"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(90)90003-7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.17.6912"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0742074.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00529.2002"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01231-7"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00294-8"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5479.633"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0485-2_51"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-08-02332.1991"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91426-S"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-10-03729.1992"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91782-N"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90220-8"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050545"},{"key":"e_1_3_3_38_2","unstructured":"Capper-Loup C. 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