{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:07:12Z","timestamp":1792570032448,"version":"4.5.0"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,1,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The carotid body chemosensory reflex is a principal regulator of breathing and blood pressure. Humans and experimental animals display marked interindividual variation in the carotid body chemosensory reflex; however, the underlying mechanisms are not known. Here, we demonstrate differences in carotid body O\n                    <jats:sub>2<\/jats:sub>\n                    sensing to be mediated by inherent variations in carbon monoxide-sensitive hydrogen sulfide signaling in three distinct rat strains. Hyposensitivity of the carotid body to hypoxia was associated with higher CO and lower H\n                    <jats:sub>2<\/jats:sub>\n                    S levels, poor ventilatory adaptation to hypobaric hypoxia, and pulmonary edema. Hypersensitivity of the carotid body to low O\n                    <jats:sub>2<\/jats:sub>\n                    was accompanied by reduced CO, greater H\n                    <jats:sub>2<\/jats:sub>\n                    S generation, and hypertension.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1322172111","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T23:30:23Z","timestamp":1389051023000},"page":"1174-1179","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Inherent variations in CO-H\n                    <sub>2<\/sub>\n                    S-mediated carotid body O\n                    <sub>2<\/sub>\n                    sensing mediate hypertension and pulmonary edema"],"prefix":"10.1073","volume":"111","author":[{"given":"Ying-Jie","family":"Peng","sequence":"first","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav V.","family":"Makarenko","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasri","family":"Nanduri","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag","family":"Vasavda","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"},{"name":"The Solomon H. Snyder Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Raghuraman","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moataz M.","family":"Gadalla","sequence":"additional","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience,"},{"name":"Department of Pharmacology and Molecular Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh K.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon H.","family":"Snyder","sequence":"additional","affiliation":[{"name":"The Solomon H. Snyder Department of Neuroscience,"},{"name":"Department of Pharmacology and Molecular Sciences, and"},{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanduri R.","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(03)00048-X"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1982.62.1.262"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.3.1268"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.3.1152"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08111825"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.6.562"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.206946"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00019.2002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.1.317"},{"key":"e_1_3_3_10_2","first-page":"R1371","article-title":"Differential control of ventilation among inbred strains of mice","volume":"267","author":"Tankersley CG","year":"1994","unstructured":"CG Tankersley, RS Fitzgerald, SR Kleeberger, Differential control of ventilation among inbred strains of mice. 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