{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:18:30Z","timestamp":1793038710966,"version":"4.5.0"},"reference-count":33,"publisher":"National Academy of Sciences","issue":"39","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,9,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Thought depends on the brain, and cognitive neuroscience has shown that different sets of brain regions (systems) support different cognitive abilities. We hypothesized that complex cognition might be especially supported by hub brain locations that participate in many such systems. We studied neurological patients with focal brain lesions, and found that damage to hub locations produced much greater cognitive impairment than damage to other locations. This work may improve the understanding of outcomes of brain injuries (from, e.g., stroke, resection, or trauma) and help inform prognosis and rehabilitation efforts.<\/jats:p>","DOI":"10.1073\/pnas.1322173111","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T04:31:40Z","timestamp":1410841900000},"page":"14247-14252","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":256,"title":["Network measures predict neuropsychological outcome after brain injury"],"prefix":"10.1073","volume":"111","author":[{"given":"David E.","family":"Warren","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Power","sequence":"additional","affiliation":[{"name":"Departments of bNeurology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Bruss","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L.","family":"Denburg","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242;"},{"name":"Department of Psychology, University of Iowa, Iowa City, IA 52242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Departments of bNeurology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Departments of bNeurology,"},{"name":"Radiology,"},{"name":"Anatomy and Neurobiology, and"},{"name":"Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Departments of fPsychology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tranel","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242;"},{"name":"Department of Psychology, University of Iowa, Iowa City, IA 52242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00222"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002431107"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ana.21905","article-title":"Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke","volume":"67","author":"Carter AR","year":"2010","unstructured":"AR Carter, et al., Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke. Ann Neurol 67, 365\u2013375 (2010).","journal-title":"Ann Neurol"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.02.013"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060159"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.11.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.024"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr269"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.035"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.063"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0570-13.2013"},{"key":"e_1_3_3_15_2","volume-title":"Neuropsychological Assessment","author":"Lezak MD","year":"2012","unstructured":"MD Lezak, DB Howieson, ED Bigler, D Tranel Neuropsychological Assessment (Oxford Univ Press, New York, 2012)."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.070"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007928107"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1604-270"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31813e0a32"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000289344"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afm014"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2011.01650.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2007.08.001"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.388"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022626"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199910)46:4<568::AID-ANA4>3.0.CO;2-R"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.055657"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420206"},{"key":"e_1_3_3_29_2","first-page":"212","article-title":"Estimates of segregation and overlap of functional connectivity networks in the human cerebral cortex","volume":"88","author":"Yeo BT","year":"2013","unstructured":"BT Yeo, FM Krienen, MW Chee, RL Buckner, Estimates of segregation and overlap of functional connectivity networks in the human cerebral cortex. Neuroimage 88C, 212\u2013227 (2013).","journal-title":"Neuroimage"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09182"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706851105"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530260037016"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.025"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1322173111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T10:52:25Z","timestamp":1717325545000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1322173111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,15]]},"references-count":33,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2014,9,30]]}},"alternative-id":["10.1073\/pnas.1322173111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1322173111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,15]]},"assertion":[{"value":"2014-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}