{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:43:41Z","timestamp":1790084621608,"version":"4.0.1"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,5,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Secretion of protein products from cells is crucial during development, as well as in adult tissues, where secreted factors perform specialized functions. Previous studies demonstrated that an essential, conserved protein modification (O-glycosylation) affected secretion in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    and mammalian tissues. However, the mechanisms by which secretion was affected were unknown. Here we demonstrate that this protein modification affects secretory vesicle formation and polarized secretion by protecting an essential endoplasmic reticulum\/Golgi transmembrane protein (Tango1) from protease cleavage. Moreover, we identify the specific enzyme (PGANT4) and furin protease (Dfur2) that form this regulatory partnership. Finally, our results have implications for the treatment of human diseases resulting from the loss of this protein modification by modulating the activity of specific proteases in vivo.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1322264111","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T01:45:42Z","timestamp":1399340742000},"page":"7296-7301","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["O-Glycosylation regulates polarized secretion by modulating Tango1 stability"],"prefix":"10.1073","volume":"111","author":[{"given":"Liping","family":"Zhang","sequence":"first","affiliation":[{"name":"Developmental Glycobiology Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfeqhar Ali","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Institute of Biomedicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"van Dijk H\u00e4rd","sequence":"additional","affiliation":[{"name":"Institute of Health and Care Sciences, University of Gothenburg, SE-405 30 Gothenburg, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Min","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Changwon National University, Changwon, Gyeongnam 641-773, South Korea; and"},{"name":"Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly G.","family":"Ten Hagen","sequence":"additional","affiliation":[{"name":"Developmental Glycobiology Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.35"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237910"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069094"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.020"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061929"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901454106"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04377"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwr182"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.418558"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1358"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0877"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/4371252a"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.133561"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606268200"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.098145"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1874"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.306159"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401310202"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003041"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007162"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.12.025"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-02-0143"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.3.1020"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj051"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602469200"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.79"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1731"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45538"},{"key":"e_1_3_3_29_2","first-page":"885","article-title":"Reduced expression of TANGO in colon and hepatocellular carcinomas","volume":"18","author":"Arndt S","year":"2007","unstructured":"S Arndt, AK Bosserhoff, Reduced expression of TANGO in colon and hepatocellular carcinomas. 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