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Here we investigated the antitumor effects of the latest series of highly potent GHRH antagonists\u2014MIA-602, MIA-606, and MIA-690\u2014on androgen-dependent as well as CRPC lines expressing receptors for GHRH. MIA-602 inhibited in vivo growth of both androgen-dependent and CRPCs and decreased cell proliferation in vitro. This study provides evidence of the preclinical efficacy of GHRH antagonist MIA-602 in the treatment of human prostate cancer.<\/jats:p>","DOI":"10.1073\/pnas.1323102111","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T23:30:23Z","timestamp":1389051023000},"page":"1084-1089","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["Preclinical efficacy of growth hormone-releasing hormone antagonists for androgen-dependent and castration-resistant human prostate cancer"],"prefix":"10.1073","volume":"111","author":[{"given":"Cale D.","family":"Fahrenholtz","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc G.","family":"Rick","sequence":"additional","affiliation":[{"name":"Endocrine, Polypeptide, and Cancer Institute and South Florida Veterans Affairs Foundation for Research and Education, Veterans Affairs Medical Center, Miami, FL 33125;"},{"name":"Department of Urology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33174; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Zarandi","sequence":"additional","affiliation":[{"name":"Endocrine, Polypeptide, and Cancer Institute and South Florida Veterans Affairs Foundation for Research and Education, Veterans Affairs Medical Center, Miami, FL 33125;"},{"name":"Department of Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Zhi","family":"Cai","sequence":"additional","affiliation":[{"name":"Endocrine, Polypeptide, and Cancer Institute and South Florida Veterans Affairs Foundation for Research and Education, Veterans Affairs Medical Center, Miami, FL 33125;"},{"name":"Department of Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman L.","family":"Block","sequence":"additional","affiliation":[{"name":"Endocrine, Polypeptide, and Cancer Institute and South Florida Veterans Affairs Foundation for Research and Education, Veterans Affairs Medical Center, Miami, FL 33125;"},{"name":"Department of Pathology and"},{"name":"Divisions of Hematology\/Oncology and Endocrinology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Schally","sequence":"additional","affiliation":[{"name":"Endocrine, Polypeptide, and Cancer Institute and South Florida Veterans Affairs Foundation for Research and Education, Veterans Affairs Medical Center, Miami, FL 33125;"},{"name":"Department of Pathology and"},{"name":"Divisions of Hematology\/Oncology and Endocrinology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry L.","family":"Burnstein","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.834328"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S32426"},{"key":"e_1_3_3_4_2","article-title":"Androgens regulate prostate cancer cell growth via an AMPK-PGC-1\u03b1 mediated metabolic switch","author":"Tennakoon JB","year":"2013","unstructured":"JB Tennakoon, et al., Androgens regulate prostate cancer cell growth via an AMPK-PGC-1\u03b1 mediated metabolic switch. 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