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Fatal cases showed evidence for previous vaccination against polioviruses and the outbreak virus was refractive against neutralization by monoclonal and vaccine-derived antibodies. This pointed to immune escape contributing to the severity of the outbreak. Sustained vaccination regimens in polio-free regions, together with clinical and environmental poliovirus surveillance will be necessary to combat antigenetically variant polioviruses in the poliomyelitis eradication endgame.<\/jats:p>","DOI":"10.1073\/pnas.1323502111","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T02:18:04Z","timestamp":1408414684000},"page":"12889-12894","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010"],"prefix":"10.1073","volume":"111","author":[{"given":"Jan Felix","family":"Drexler","sequence":"first","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Grard","sequence":"additional","affiliation":[{"name":"Centre International de Recherches M\u00e9dicales de Franceville, BP 769 Franceville, Gabon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Lukashev","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov I.","family":"Kozlovskaya","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindy","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Robert Koch Institute, National Reference Laboratory for Poliomyelitis and Enteroviruses, 13302 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Uslu","sequence":"additional","affiliation":[{"name":"Netherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Reimerink","sequence":"additional","affiliation":[{"name":"Netherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly P.","family":"Gmyl","sequence":"additional","affiliation":[{"name":"Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow 142782, Russia;"},{"name":"Lomonosov Moscow State University, Moscow 119991, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Taty-Taty","sequence":"additional","affiliation":[{"name":"Ministry of Health, Pointe Noire, Republic of Congo; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Etenna","family":"Lekana-Douki","sequence":"additional","affiliation":[{"name":"Centre International de Recherches M\u00e9dicales de Franceville, BP 769 Franceville, Gabon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieudonn\u00e9","family":"Nkoghe","sequence":"additional","affiliation":[{"name":"Centre International de Recherches M\u00e9dicales de Franceville, BP 769 Franceville, Gabon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Eis-H\u00fcbinger","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Diedrich","sequence":"additional","affiliation":[{"name":"Robert Koch Institute, National Reference Laboratory for Poliomyelitis and Enteroviruses, 13302 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Koopmans","sequence":"additional","affiliation":[{"name":"Netherlands Center for Infectious Disease Control, 3720, Bilthoven, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Leroy","sequence":"additional","affiliation":[{"name":"Centre International de Recherches M\u00e9dicales de Franceville, BP 769 Franceville, Gabon;"},{"name":"Institut de Recherche pour le D\u00e9veloppement, Unit\u00e9 Mixte de Recherche 224 (Maladies Infectieuses et Vecteurs: \u00c9cologie, G\u00e9n\u00e9tique, \u00c9volution et Contr\u00f4le), Institut de Recherche pour le D\u00e9veloppement\/Centre National de la Recherche Scientifique\/Unit\u00e9 Mixte 1, 34032 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Drosten","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,8,18]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/aje\/kwq320","article-title":"From emergence to eradication: The epidemiology of poliomyelitis deconstructed","volume":"172","author":"Nathanson N","year":"2010","unstructured":"N Nathanson, OM Kew, From emergence to eradication: The epidemiology of poliomyelitis deconstructed. 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MMWR Morb Mortal Wkly Rep 60, 306\u2013311 (2011).","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/cid\/cis720","article-title":"Research and development and the polio eradication initiative: Too much, too soon...too little, too late?","volume":"55","author":"Patriarca PA","year":"2012","unstructured":"PA Patriarca, Research and development and the polio eradication initiative: Too much, too soon...too little, too late? Clin Infect Dis 55, 1307\u20131311 (2012).","journal-title":"Clin Infect Dis"},{"key":"e_1_3_4_4_2","unstructured":"The Global Polio Eradication Initiative (2014) Wild Poliovirus (WPV) cases. Available at www.polioeradication.org\/Dataandmonitoring\/Poliothisweek.aspx. 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