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Disease modeling with patient-derived iPSCs may provide significant insights into phenotypic variability associated with mutations in various genes along the same pathway and may serve as a platform to explore tissue-specific consequences of single gene defects and development of therapeutic interventions.<\/jats:p>","DOI":"10.1073\/pnas.1323649111","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T02:56:28Z","timestamp":1401764188000},"page":"8889-8894","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells"],"prefix":"10.1073","volume":"111","author":[{"given":"Kerstin","family":"Felgentreff","sequence":"first","affiliation":[{"name":"Division of Immunology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likun","family":"Du","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja G.","family":"Weinacht","sequence":"additional","affiliation":[{"name":"Division of Immunology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"},{"name":"Division of Pediatric Hematology\/Oncology, Boston Children\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Dobbs","sequence":"additional","affiliation":[{"name":"Division of Immunology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Bartish","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Giliani","sequence":"additional","affiliation":[{"name":"A. 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