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The success of this approach will depend on the contribution to transmission by older ages, which we estimated during two large outbreaks affecting adults. Their contribution was found to depend on the setting, but there was no evidence for imperfect immunity contributing to the transmission of infection. Even small gains in the speed of vaccination response were found to have substantially greater benefit compared with expanded age range campaigns.<\/jats:p>","DOI":"10.1073\/pnas.1323688111","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T23:01:33Z","timestamp":1404774093000},"page":"10604-10609","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["The role of older children and adults in wild poliovirus transmission"],"prefix":"10.1073","volume":"111","author":[{"given":"Isobel M.","family":"Blake","sequence":"first","affiliation":[{"name":"Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Martin","sequence":"additional","affiliation":[{"name":"Regional Office for Europe, World Health Organization, DK-2100 Copenhagen, Denmark;"},{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Goel","sequence":"additional","affiliation":[{"name":"Polio and Emergencies Cluster, World Health Organization, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Khetsuriani","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Everts","sequence":"additional","affiliation":[{"name":"Polio and Emergencies Cluster, World Health Organization, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wolff","sequence":"additional","affiliation":[{"name":"Polio and Emergencies Cluster, World Health Organization, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Wassilak","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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