{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:09:30Z","timestamp":1793725770089,"version":"4.6.1"},"reference-count":20,"publisher":"National Academy of Sciences","issue":"24","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,6,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Genome-wide association studies have uncovered a genetic locus in chromosome 19 associated with the plasma triglyceride (TG) concentration, a risk factor for coronary heart disease. The identity and functional role of the gene responsible for this association is unknown. Gene expression analysis of 206 human liver samples led to the identification of transmembrane 6 superfamily member 2 (\n                    <jats:italic>TM6SF2<\/jats:italic>\n                    ), a gene with hitherto unknown function, as the putative causal gene. Functional studies in human liver cells demonstrated that inhibition of\n                    <jats:italic>TM6SF2<\/jats:italic>\n                    was associated with reduced secretion of TG-rich lipoproteins (TRLs) and increased cellular TG concentration, while\n                    <jats:italic>TM6SF2<\/jats:italic>\n                    overexpression reduced cellular TG concentration. We conclude that TM6SF2 is a novel regulator of liver fat metabolism with opposing effects on the secretion of TRLs and hepatic TG content.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1323785111","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T23:43:54Z","timestamp":1401925434000},"page":"8913-8918","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":352,"title":["TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content"],"prefix":"10.1073","volume":"111","author":[{"given":"Hovsep","family":"Mahdessian","sequence":"first","affiliation":[{"name":"Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Taxiarchis","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergej","family":"Popov","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Silveira","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Franco-Cereceda","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Hamsten","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"van't Hooft","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Solna, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.76"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.75"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.269"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.291"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09270"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2797"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001324"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000346195"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2795"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2383"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.12.022"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09266"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056784"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg509"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-6-49"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.201426"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2901"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2926"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027481"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.948935"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1323785111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:33:14Z","timestamp":1649806394000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1323785111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":20,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2014,6,17]]}},"alternative-id":["10.1073\/pnas.1323785111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1323785111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]},"assertion":[{"value":"2014-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}