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Although an effective universal vaccine that can protect from influenza viruses from different subtypes or even both type A and B is still far from reality, our unique findings, showing that monosaccharide glycosylated HA vaccine induces broader protection against different strains, may lead to a better influenza vaccine design that does not require frequent updates and annual immunizations. This strategy may also map out a new direction for development of universal flu vaccines and be applied to vaccine design for other human viruses.<\/jats:p>","DOI":"10.1073\/pnas.1323954111","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:29:52Z","timestamp":1390868992000},"page":"2476-2481","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections"],"prefix":"10.1073","volume":"111","author":[{"given":"Juine-Ruey","family":"Chen","sequence":"first","affiliation":[{"name":"Genomics Research Center, Academia Sinica, Taipei 115, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Hsiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Genomics Research Center, Academia Sinica, Taipei 115, 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