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Human patients and mouse models lacking seipin in germ cells produce severely abnormal sperm because of impaired lipid distribution during sperm maturation. These defects are testis-intrinsic; scarcity of adipose tissue per se does not affect male fertility. Our work shows that two distinct organs\u2014adipose tissue and the male germ line\u2014depend on seipin function and that appropriate lipid distribution is essential for production of mature, functional sperm.<\/jats:p>","DOI":"10.1073\/pnas.1324025111","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T03:37:37Z","timestamp":1398742657000},"page":"7054-7059","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Lack of testicular seipin causes teratozoospermia syndrome in men"],"prefix":"10.1073","volume":"111","author":[{"given":"Min","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of 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