{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:50:24Z","timestamp":1787997024144,"version":"build-2784847793"},"reference-count":47,"publisher":"National Academy of Sciences","issue":"43","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,10,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The rise in obesity-associated diseases has led to increased efforts to identify new therapeutic targets. Lipid accumulation in obesity triggers a low-grade inflammation that links obesity to its associated diseases, notably insulin resistance and type 2 diabetes. In this report, we have studied a group of innate-like B lymphocytes in visceral white adipose tissue (VAT) of mice that are (\n                    <jats:italic>i<\/jats:italic>\n                    ) capable of producing the anti-inflammatory mediator IL-10; (\n                    <jats:italic>ii<\/jats:italic>\n                    ) replenished from precursor cells in spleen during diet-induced obesity (DIO); and (\n                    <jats:italic>iii<\/jats:italic>\n                    ) impaired in VAT of DIO mice, resulting in diminished protection against obesity-associated insulin resistance that can be ameliorated by supplementation of these cells. These findings identify spleen-supplied innate-like B cells in VAT as previously unidentified therapeutic targets for obesity-associated diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1324052111","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:15Z","timestamp":1413244815000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance"],"prefix":"10.1073","volume":"111","author":[{"given":"Lan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrajesh V.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba 278-0022, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Kaer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2627"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57132"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101322"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2922"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230721"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.04.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.05.011"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1964"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2353"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215840110"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2901"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3369"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.05.023"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3907"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074934"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3384"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4161\/adip.22296"},{"key":"e_1_3_3_19_2","unstructured":"S Nishimura Adipose natural regulatory B cells negatively control adipose tissue inflammation. 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