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The mediation by cyclic AMP-dependent protein kinase of L-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -current (I\n                    <jats:sub>Ca,L<\/jats:sub>\n                    ) responses to agonists, lusitropy, and protein phosphorylation are preserved in AF. The vanishing of agonist-evoked arrhythmias in AF is associated with the disappearance of an I\n                    <jats:sub>Ca,L<\/jats:sub>\n                    response, facilitated by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/calmodulin-dependent kinase II (CaMKII), in myocytes from patients with SR, and decreased phosphorylation of phospholamban, but not ryanodine, by this enzyme. The disappearance of arrhythmias and associated reduction of CaMKII functions questions the use of CaMKII inhibitors in AF, as has been proposed by other groups.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1324132111","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T01:15:59Z","timestamp":1405386959000},"page":"11193-11198","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":80,"title":["Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation"],"prefix":"10.1073","volume":"111","author":[{"given":"Torsten","family":"Christ","sequence":"first","affiliation":[{"name":"Departments of aPharmacology and Toxicology and"},{"name":"Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadiia","family":"Rozmaritsa","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and Toxicology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Engel","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and Toxicology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Berk","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and Toxicology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Knaut","sequence":"additional","affiliation":[{"name":"Heart Surgery, Dresden University of Technology, 01307 Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Metzner","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and Toxicology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Canteras","sequence":"additional","affiliation":[{"name":"Departments of dBiostatistics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Ravens","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and Toxicology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Kaumann","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany; 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