{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:03:48Z","timestamp":1791515028035,"version":"4.3.4"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,7,8]]},"abstract":"<jats:p>\n                    Overexpression of c-Myc is one of the most common alterations in human\n cancers, yet it is not clear how this transcription factor acts to promote\n malignant transformation. To understand the molecular targets of c-Myc\n function, we have used an unbiased genome-wide location-analysis approach to\n examine the genomic binding sites of c-Myc in Burkitt's lymphoma cells. We\n find that c-Myc together with its heterodimeric partner, Max, occupy &gt;15%\n of gene promoters tested in these cancer cells. The DNA binding of c-Myc and\n Max correlates extensively with gene expression throughout the genome, a\n hallmark attribute of general transcription factors. The c-Myc\/Max heterodimer\n complexes also colocalize with transcription factor IID in these cells,\n further supporting a general role for overexpressed c-Myc in global gene\n regulation. In addition, transcription of a majority of c-Myc target genes\n exhibits changes correlated with levels of c-\n                    <jats:italic>myc<\/jats:italic>\n                    mRNA in a diverse\n set of tissues and cell lines, supporting the conclusion that c-Myc regulates\n them. Taken together, these results suggest a general role for overexpressed\n c-Myc in global transcriptional regulation in some cancer cells and point\n toward molecular mechanisms for c-Myc function in malignant\n transformation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1332764100","type":"journal-article","created":{"date-parts":[[2003,7,8]],"date-time":"2003-07-08T15:18:15Z","timestamp":1057677495000},"page":"8164-8169","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":413,"title":["A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells"],"prefix":"10.1073","volume":"100","author":[{"given":"Zirong","family":"Li","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research and\r Departments of Cellular and Molecular Medicine\r and Medicine, University of California at San\r Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653; and\r Cold Spring Harbor Laboratory, 1 Bungtown\r Road, P.O. Box 100, Cold Spring Harbor, NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Van Calcar","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research and\r Departments of Cellular and Molecular Medicine\r and Medicine, University of California at San\r Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653; and\r Cold Spring Harbor Laboratory, 1 Bungtown\r Road, P.O. Box 100, Cold Spring Harbor, NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxu","family":"Qu","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research and\r Departments of Cellular and Molecular Medicine\r and Medicine, University of California at San\r Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653; and\r Cold Spring Harbor Laboratory, 1 Bungtown\r Road, P.O. Box 100, Cold Spring Harbor, NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Webster K.","family":"Cavenee","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research and\r Departments of Cellular and Molecular Medicine\r and Medicine, University of California at San\r Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653; and\r Cold Spring Harbor Laboratory, 1 Bungtown\r Road, P.O. Box 100, Cold Spring Harbor, NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Q.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research and\r Departments of Cellular and Molecular Medicine\r and Medicine, University of California at San\r Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653; and\r Cold Spring Harbor Laboratory, 1 Bungtown\r Road, P.O. Box 100, Cold Spring Harbor, NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ren","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research and\r Departments of Cellular and Molecular Medicine\r and Medicine, University of California at San\r Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653; and\r Cold Spring Harbor Laboratory, 1 Bungtown\r Road, P.O. Box 100, Cold Spring Harbor, NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,6,13]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc904"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204595"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.16.1.653"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202748"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202746"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.21.6497"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90280-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80367-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.3940"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071489"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00738-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2251503"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.9.5216-5224.1993"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.7.5.1697-1709.1987"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102173199"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.3.1536"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.16.7804"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/35070076"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/35070086"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081074898"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(02)00020-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01327"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2306"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/35054095"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075090"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00746-8"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng907"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082249499"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng569"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066101"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.949802"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.943102"},{"key":"e_1_3_2_34_2","first-page":"1300","volume":"28","year":"1968","unstructured":"Klein, E., Klein, G., Nadkarni, J. S., Nadkarni, J. J., Wigzell, H. & Clifford, P. (1968) Cancer Res. 28, 1300-1310.4174339","journal-title":"Cancer Res."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190309"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012025199"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8489"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.2.1147-1152.1994"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/362175a0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/362179a0"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1066903"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00520-8"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1332764100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:15:59Z","timestamp":1649805359000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1332764100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,13]]},"references-count":42,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2003,7,8]]}},"alternative-id":["10.1073\/pnas.1332764100"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1332764100","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,13]]},"assertion":[{"value":"2003-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}