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We show that signal transducer and activator of transcription 3 (STAT3), a protein overactive in many human cancers, can abnormally evade recognition of DNA errors and damage leading to bypass of a critical cell-cycle checkpoint and uncontrolled cell proliferation. While relevant to understanding cancer development and prevention, this will also bring fresh insights into the role of STAT3 in the central biology of cell proliferation, particularly since STAT3 is necessary for critical processes including embryonic development and immunity.<\/jats:p>","DOI":"10.1073\/pnas.1400683111","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T01:41:09Z","timestamp":1395106869000},"page":"4946-4951","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":72,"title":["STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation"],"prefix":"10.1073","volume":"111","author":[{"given":"Siva","family":"Koganti","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases, Department of Pediatrics and Stony Brook Children\u2019s Hospital, Stony Brook University School of Medicine, Stony Brook, NY 11794;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Hui-Yuen","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Morgan Stanley Children\u2019s Hospital, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"McAllister","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases and Immunology, University of Minnesota, MN 55455;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Grasser","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Universit\u00e4tsklinkum des Saarlandes, Homburg\/Saar 66421, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umaimainthan","family":"Palendira","sequence":"additional","affiliation":[{"name":"Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;"},{"name":"St. Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW 2010, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart G.","family":"Tangye","sequence":"additional","affiliation":[{"name":"Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;"},{"name":"St. Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW 2010, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra F.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; 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