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Here we report that Mig-6 is uniquely expressed in the cells surrounding entire surface of the synovial joint, including chondrocytes in the superficial zone of the articular cartilage and in the meniscus, and synovial lining cells. We found that although chondrocytes play a critical role in developing the OA-like disorder in the knees, other cell types are likely required for full development of the Mig-6\u2013deficient joint phenotype.<\/jats:p>","DOI":"10.1073\/pnas.1400744111","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T01:33:35Z","timestamp":1391477615000},"page":"2590-2595","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":50,"title":["Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation"],"prefix":"10.1073","volume":"111","author":[{"given":"Ben","family":"Staal","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncology, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart O.","family":"Williams","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling and Carcinogenesis, Center for Skeletal Disease and Tumor Metastasis, Van Andel Research Institute, Grand Rapids, MI 49503; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Beier","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Western University, London, ON, Canada N6A 5C1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Vande Woude","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,2,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.5.3928"},{"key":"e_1_3_3_2_2","first-page":"199","volume-title":"Future Aspects of Tumor Suppressor Gene","author":"Zhang YW","year":"2013","unstructured":"YW Zhang, GF Vande Woude, MIG-6 and SPRY2 in the regulation of receptor tyrosine kinase signaling: Balancing act via negative feedback loops. 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