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Adding low pharmacologic quantities of P\n                    <jats:sub>n<\/jats:sub>\n                    to serum markedly enhanced complement deposition on\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    and\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    and dramatically boosted serum lysis of meningococci. In mouse models of infection for these two major human pathogens, a single low-dose application of P\n                    <jats:sub>n<\/jats:sub>\n                    significantly reduced bacteremia and markedly increased survival rates. Interestingly, therapeutic induction of massive complement mediated lysis of meningococci did not induce septic shock symptoms through the release of bacterial toxins.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1401011111","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T01:25:24Z","timestamp":1395710724000},"page":"5301-5306","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Low-dose recombinant properdin provides substantial protection against\n                    <i>Streptococcus pneumoniae<\/i>\n                    and\n                    <i>Neisseria meningitidis<\/i>\n                    infection"],"prefix":"10.1073","volume":"111","author":[{"given":"Youssif Mohammed","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom;"},{"name":"Department of Microbiology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom;"},{"name":"Department of Microbiology, Faculty of Health Sciences, Hazara University, Mansehra, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayad Mawlood","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif S.","family":"Haleem","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom;"},{"name":"Department of Microbiology, Faculty of Health Sciences, Hazara University, Mansehra, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Alshamrani","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom;"},{"name":"Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran, Saudi Arabia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany I.","family":"Kenawy","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom;"},{"name":"Department of Microbiology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana P.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpanna","family":"Saggu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43606;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Buchberger","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom;"},{"name":"Department of Veterinary Medicine, University of Cambridge, Cambridge CB2 1TN, United Kingdom; 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