{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:30:14Z","timestamp":1781109014540,"version":"3.54.1"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"27","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,7,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Forkhead box P3\n                    <jats:sup>+<\/jats:sup>\n                    (Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    ) regulatory T cells (Tregs) are important for maintaining immune homeostasis and tolerance. The pivotal role of Tregs in immune tolerance demands that they possess a dedicated molecular machinery to maintain stable Foxp3 expression when challenged by an inflammatory environment. Whereas epigenetic mechanisms acting on the\n                    <jats:italic>foxp3<\/jats:italic>\n                    locus have been extensively implicated in Tregs\u2019 stable expression of Foxp3, the detailed molecular machinery remains elusive. In this study, we show that methyl-CpG binding protein 2 (MeCP2), an X-linked multifunctional epigenetic regulator, is a crucial player in the epigenetic machinery that confers Tregs with resilience against inflammation. Our study provides, to our knowledge, the first mechanistic description by which MeCP2, a molecule best known for its function in the central nervous system, regulates Treg function and immune tolerance.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1401505111","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T04:39:14Z","timestamp":1403584754000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["MeCP2 enforces Foxp3 expression to promote regulatory T cells\u2019 resilience to inflammation"],"prefix":"10.1073","volume":"111","author":[{"given":"Chaoran","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunology, Duke University Medical Center, Durham, NC 27710; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center, 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