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The failure to generate new Th1 responses is mediated by chronic type I interferon (IFN-I) signaling, and its blockade effectively restored de novo Th1 development. Our study identifies a mechanism of immunosuppression and a method to restore Th1 generation during persistent infection.<\/jats:p>","DOI":"10.1073\/pnas.1401662111","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T01:45:42Z","timestamp":1399340742000},"page":"7409-7414","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":99,"title":["Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection"],"prefix":"10.1073","volume":"111","author":[{"given":"Ivan","family":"Osokine","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and"},{"name":"UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura 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