{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:47:37Z","timestamp":1790948857212,"version":"4.1.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,4,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Successful fertilization requires viable sperm and eggs to meet. Some insects, such as the\n                    <jats:italic>Anopheles gambiae<\/jats:italic>\n                    female mosquito, the principal vector of malaria, mate only once and keep sperm received from a male in a specialized sperm storage organ while eggs are developed after taking a blood meal. Sperm are kept functional for several weeks, but the factors and mechanisms that achieve this preservation are unknown in this mosquito. Here we identify a heme peroxidase HPX15 and other mechanisms activated by sex that are important to preserve the functionality of stored sperm and long-term fertility. Disrupting the reproductive cycle in field\n                    <jats:italic>Anopheles<\/jats:italic>\n                    would reduce numbers of mosquitoes transmitting malaria, aiding in the fight against one of the world\u2019s deadliest diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1401715111","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:10:32Z","timestamp":1396915832000},"page":"5854-5859","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":90,"title":["Mating activates the heme peroxidase HPX15 in the sperm storage organ to ensure fertility in\n                    <i>Anopheles gambiae<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"W. Robert","family":"Shaw","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Teodori","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universit\u00e0 di Perugia, Terni 05100, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Baldini","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universit\u00e0 di Perugia, Terni 05100, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gabrieli","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universit\u00e0 di Perugia, Terni 05100, Italy; 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