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To break this mechanism and to sustain antiviral T-cell responses, we used mice that lost Fas from DCs. These animals cleared the infection, whereas Fas-sufficient mice did not. Moreover, a transfer of Fas-negative DCs into infected mice supported the clearance of LCMV infection. Thus, we suggest a novel strategy for stimulation of T cells to achieve the clearance of persistent viruses in infected animals and humans.<\/jats:p>","DOI":"10.1073\/pnas.1401750111","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T02:22:54Z","timestamp":1401243774000},"page":"8559-8564","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection"],"prefix":"10.1073","volume":"111","author":[{"given":"Vineeth","family":"Varanasi","sequence":"first","affiliation":[{"name":"Department of Pathology and Committee on Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly Azeem","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute for Genomics and Systems Biology and Department of Human Genetics, The University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Chervonsky","sequence":"additional","affiliation":[{"name":"Department of Pathology and Committee on Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.4161\/cc.5.21.3397","article-title":"Apoptosis in activated T cells: What are the triggers, and what the signal transducers?","volume":"5","author":"H\u00e4cker G","year":"2006","unstructured":"G H\u00e4cker, A Bauer, A Villunger, Apoptosis in activated T cells: What are the triggers, and what the signal transducers? 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