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Tbx1 and p53 proteins coregulate the gene\n                    <jats:italic>Gbx2<\/jats:italic>\n                    , which is required for cardiovascular development.\n                    <jats:italic>Gbx2<\/jats:italic>\n                    expression is positively regulated by Tbx1, whereas suppression of p53 results in reduced levels of the repressive chromatin mark H3K27me3 at a genetic element occupied by both Tbx1 and p53. These data illustrate a mechanism by which reduced p53, by genetic or pharmacological means, can counterbalance the consequences of reduced dosage of Tbx1.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1401923111","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T23:56:19Z","timestamp":1409702179000},"page":"13385-13390","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["p53 suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome"],"prefix":"10.1073","volume":"111","author":[{"given":"Cinzia","family":"Caprio","sequence":"first","affiliation":[{"name":"Open University PhD Program,"},{"name":"Consiglio Nazionale delle Ricerche Institute of Genetics and Biophysics Adriano Buzzati Traverso, 80131 Naples, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Baldini","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche Institute of Genetics and Biophysics Adriano Buzzati Traverso, 80131 Naples, Italy; and"},{"name":"Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.75"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14632-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600206103"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.200295"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(10)90001-X"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215360109"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.10.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01174"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.08.031"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10940"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001268"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1211"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02208"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101866"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.19.13301"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.05.023"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.028902"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/35065105"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00247-1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/85845"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5434.1733"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02018"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm291"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.270223"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002571"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.338996"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02086"},{"key":"e_1_3_3_28_2","first-page":"3301","article-title":"Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice","volume":"119","author":"Randall V","year":"2009","unstructured":"V Randall, et al., Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. 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