{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:28:56Z","timestamp":1791131336937,"version":"4.1.0"},"reference-count":76,"publisher":"National Academy of Sciences","issue":"29","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,7,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Connections are crucial to brain function and a variety of molecular systems direct axonal growth during development and regeneration. An important system involves Celsr2, Celsr3, and Fzd3, membrane proteins that also regulate epithelial planar cell polarity (PCP). Here, we show genetically that Celsr2 and Celsr3 guide axons redundantly, in collaboration with Fzd3 in the same cell populations. However, unlike in epithelial PCP, their action is Vangl1 and Vangl2 independent. Furthermore, expression of Celsr2-3 and Fzd3 in thalamocortical axons and cortical cells is required for the fine mapping of cortical areas. Our findings that Celsr2, Celsr3, and Fzd3 regulate axonal guidance using mechanisms different than epithelial PCP have implications for brain wiring during normal development and regeneration.<\/jats:p>","DOI":"10.1073\/pnas.1402105111","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T23:01:33Z","timestamp":1404774093000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["Genetic evidence that\n                    <i>Celsr3<\/i>\n                    and\n                    <i>Celsr2<\/i>\n                    , together with\n                    <i>Fzd3<\/i>\n                    , regulate forebrain wiring in a\n                    <i>Vangl<\/i>\n                    -independent manner"],"prefix":"10.1073","volume":"111","author":[{"given":"Yibo","family":"Qu","sequence":"first","affiliation":[{"name":"Guangdong\u2013Hong Kong\u2013Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong\u2013Hong Kong\u2013Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangdong\u2013Hong Kong\u2013Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Alvarez-Bolado","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy, Heidelberg University, D-69120 Heidelberg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Grove","sequence":"additional","affiliation":[{"name":"Neuroscience, The University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Yang","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadel","family":"Tissir","sequence":"additional","affiliation":[{"name":"WELBIO - Walloon Excellence in Life Sciences and Biotechnology and Institute of Neuroscience, University of Louvain, B1200 Brussels, Belgium; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong\u2013Hong Kong\u2013Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China;"},{"name":"State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre M.","family":"Goffinet","sequence":"additional","affiliation":[{"name":"WELBIO - Walloon Excellence in Life Sciences and Biotechnology and Institute of Neuroscience, University of Louvain, B1200 Brussels, Belgium; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,7,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072165"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1428"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08563.2002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3525"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02772"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.42.110807.091432"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.054080"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02677"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.03.068"},{"key":"e_1_3_3_11_2","first-page":"113","article-title":"Development of the mouse anterior commissure. Part II. A comparison of glial differentiation in the anterior and posterior limbs of the anterior commissure of the mouse brain during myelination using semithin light microscopic sections","volume":"5","author":"Sturrock RR","year":"1976","unstructured":"RR Sturrock, Development of the mouse anterior commissure. Part II. A comparison of glial differentiation in the anterior and posterior limbs of the anterior commissure of the mouse brain during myelination using semithin light microscopic sections. Zentralbl Veterinarmed [C] 5, 113\u2013121 (1976).","journal-title":"Zentralbl Veterinarmed [C]"},{"key":"e_1_3_3_12_2","first-page":"54","article-title":"Development of the mouse anterior commissure. Part I. A comparison of myelination in the anterior and posterior limbs of the anterior commissure of the mouse brain","volume":"5","author":"Sturrock RR","year":"1976","unstructured":"RR Sturrock, Development of the mouse anterior commissure. Part I. A comparison of myelination in the anterior and posterior limbs of the anterior commissure of the mouse brain. Zentralbl Veterinarmed [C] 5, 54\u201367 (1976).","journal-title":"Zentralbl Veterinarmed [C]"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.10.127"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.024"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.05.003"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324215111"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08119.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.042"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00037"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3586"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.036"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155244"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406399111"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2555"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0124-10.2010"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3221-05.2006"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01482"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06309.2002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20256"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1784"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4698-05.2005"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.84"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4508-10.2010"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.01.002"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712126105"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09129"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402802101"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9732"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.04.048"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00167.2003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21461"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1629-07.2007"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20356"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.11.031"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93935-Q"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00084-2"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131137"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.09.017"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1933"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.07.007"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00147-8"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00841-2"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00176-4"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.068668"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00374-9"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02347"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2040"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4680-05.2006"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.104"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031988"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00526"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002257"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.01.044"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.03.030"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.09.009"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1592107"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.06.014"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.08.006"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.03.062"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0618-06.2006"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3454"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<106::AID-GENE30>3.0.CO;2-T"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008868325009"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1620"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02209"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10054"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1402105111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:35:24Z","timestamp":1649806524000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1402105111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,7]]},"references-count":76,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2014,7,22]]}},"alternative-id":["10.1073\/pnas.1402105111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1402105111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,7]]},"assertion":[{"value":"2014-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}