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Apical endocytosis of the megalin\u2013cubilin ligand albumin and of fluid phase markers is markedly increased upon exposure to FSS. Moreover, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling mediated by the primary cilia on PT cells is required for this response. These studies define a novel pathway in PT cells that plays an essential role in maintaining kidney function.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1402195111","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T02:22:54Z","timestamp":1401243774000},"page":"8506-8511","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":150,"title":["Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia"],"prefix":"10.1073","volume":"111","author":[{"given":"Venkatesan","family":"Raghavan","sequence":"first","affiliation":[{"name":"Renal-Electrolyte Division, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Rbaibi","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte Division, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria M.","family":"Pastor-Soler","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte Division, Department of Medicine, and"},{"name":"Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo D.","family":"Carattino","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte Division, Department of Medicine, and"},{"name":"Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ora A.","family":"Weisz","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte Division, Department of Medicine, and"},{"name":"Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007121326"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00453.2010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00022.2012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1381-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.124"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00002.2010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405179101"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00255.2005"},{"key":"e_1_3_3_9_2","first-page":"F239","article-title":"Kinetics of endocytosis in renal proximal tubule studied with ruthenium red as membrane marker","volume":"264","author":"Birn H","year":"1993","unstructured":"H Birn, EI Christensen, S Nielsen, Kinetics of endocytosis in renal proximal tubule studied with ruthenium red as membrane marker. 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