{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:35:31Z","timestamp":1791286531122,"version":"4.1.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"27","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,7,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Mammalian target of rapamycin complex 1 (mTORC1) inhibitors are commonly used as immunosuppressants in solid-organ transplantation and as antiproliferative agents in various cancers. Despite indications of serious renal adverse events caused by mTORC1 inhibition, the role of mTORC1 for renal epithelial function and homeostasis has remained elusive. Unexpectedly, tubular mTORC1 controls energy-driven urine-concentrating mechanisms by maintaining mitochondrial biogenesis. Under pathophysiological conditions, mTORC1-dependent mitochondrial biogenesis is essential for energy supply and adaptation in response to ischemia. These findings identify mTORC1 as an important regulator of tubular energy metabolism, transcellular transport processes, and ischemic stress responses.<\/jats:p>","DOI":"10.1073\/pnas.1402352111","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T04:39:14Z","timestamp":1403584754000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":101,"title":["mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress"],"prefix":"10.1073","volume":"111","author":[{"given":"Florian","family":"Grahammer","sequence":"first","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Haenisch","sequence":"additional","affiliation":[{"name":"Renal Division, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Steinhardt","sequence":"additional","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Sandner","sequence":"additional","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Roerden","sequence":"additional","affiliation":[{"name":"Renal Division, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Arnold","sequence":"additional","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomke","family":"Cordts","sequence":"additional","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Wanner","sequence":"additional","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"},{"name":"Spemann Graduate School of Biology and Medicine,"},{"name":"Faculty of Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Reichardt","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University Medical Center Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dontscho","family":"Kerjaschki","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vienna, 1090 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus A.","family":"Ruegg","sequence":"additional","affiliation":[{"name":"Biozentrum Basel, University of Basel, 4056 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Hall","sequence":"additional","affiliation":[{"name":"Biozentrum Basel, University of Basel, 4056 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Moulin","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research, Preclinical Safety, Discovery and Investigative Safety, 4002 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Busch","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Cell Research, and"},{"name":"German Cancer Consortium, 69120 Heidelberg, Germany; and"},{"name":"German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Boerries","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Cell Research, and"},{"name":"German Cancer Consortium, 69120 Heidelberg, Germany; and"},{"name":"German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Walz","sequence":"additional","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruh","family":"Artunc","sequence":"additional","affiliation":[{"name":"Renal Division, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias B.","family":"Huber","sequence":"additional","affiliation":[{"name":"Renal Division, University Medical Center Freiburg, 79106 Freiburg, Germany;"},{"name":"Spemann Graduate School of Biology and Medicine,"},{"name":"Centre for Biological Signalling Studies, Albert Ludwigs University of Freiburg, 79104 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,6,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0002-9629(15)40679-2","article-title":"Physiology of renal sodium transport","volume":"319","author":"Greger R","year":"2000","unstructured":"R Greger, Physiology of renal sodium transport. Am J Med Sci 319, 51\u201362 (2000).","journal-title":"Am J Med Sci"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1681\/ASN.2010080827","article-title":"The WNK kinase network regulating sodium, potassium, and blood pressure","volume":"22","author":"Hoorn EJ","year":"2011","unstructured":"EJ Hoorn, JH Nelson, JA McCormick, DH Ellison, The WNK kinase network regulating sodium, potassium, and blood pressure. J Am Soc Nephrol 22, 605\u2013614 (2011).","journal-title":"J Am Soc Nephrol"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/MNH.0b013e3283484b06","article-title":"Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters","volume":"20","author":"Mercier-Zuber A","year":"2011","unstructured":"A Mercier-Zuber, KM O\u2019Shaughnessy, Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters. Curr Opin Nephrol Hypertens 20, 534\u2013540 (2011).","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"e_1_3_4_4_2","first-page":"F357","article-title":"Stoichiometry and coupling of active transport to oxidative metabolism in epithelial tissues","volume":"240","author":"Mandel LJ","year":"1981","unstructured":"LJ Mandel, RS Balaban, Stoichiometry and coupling of active transport to oxidative metabolism in epithelial tissues. Am J Physiol 240, F357\u2013F371 (1981).","journal-title":"Am J Physiol"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ki.1986.2","article-title":"Primary active sodium transport, oxygen consumption, and ATP: Coupling and regulation","volume":"29","author":"Mandel LJ","year":"1986","unstructured":"LJ Mandel, Primary active sodium transport, oxygen consumption, and ATP: Coupling and regulation. Kidney Int 29, 3\u20139 (1986).","journal-title":"Kidney Int"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1146\/annurev.ph.48.030186.000301","article-title":"ATP and the regulation of renal cell function","volume":"48","author":"Soltoff SP","year":"1986","unstructured":"SP Soltoff, ATP and the regulation of renal cell function. Annu Rev Physiol 48, 9\u201331 (1986).","journal-title":"Annu Rev Physiol"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger S","year":"2006","unstructured":"S Wullschleger, R Loewith, MN Hall, TOR signaling in growth and metabolism. Cell 124, 471\u2013484 (2006).","journal-title":"Cell"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1126\/science.1715094","article-title":"Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast","volume":"253","author":"Heitman J","year":"1991","unstructured":"J Heitman, NR Movva, MN Hall, Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253, 905\u2013909 (1991).","journal-title":"Science"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","article-title":"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton","volume":"14","author":"Sarbassov DD","year":"2004","unstructured":"DD Sarbassov, et al., Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14, 1296\u20131302 (2004).","journal-title":"Curr Biol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/ncb1183","article-title":"Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive","volume":"6","author":"Jacinto E","year":"2004","unstructured":"E Jacinto, et al., Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6, 1122\u20131128 (2004).","journal-title":"Nat Cell Biol"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim DH","year":"2002","unstructured":"DH Kim, et al., mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163\u2013175 (2002).","journal-title":"Cell"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(02)00833-4","article-title":"Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action","volume":"110","author":"Hara K","year":"2002","unstructured":"K Hara, et al., Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110, 177\u2013189 (2002).","journal-title":"Cell"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante M","year":"2012","unstructured":"M Laplante, DM Sabatini, mTOR signaling in growth control and disease. Cell 149, 274\u2013293 (2012).","journal-title":"Cell"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2011.06.034","article-title":"mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway","volume":"146","author":"Peterson TR","year":"2011","unstructured":"TR Peterson, et al., mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146, 408\u2013420 (2011).","journal-title":"Cell"},{"key":"e_1_3_4_15_2","first-page":"1153","article-title":"Effects of rapamycin on renal hemodynamics, water and sodium excretion, and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide, and vasopressin in pigs","volume":"58","author":"Golbaekdal K","year":"1994","unstructured":"K Golbaekdal, CB Nielsen, JC Djurhuus, EB Pedersen, Effects of rapamycin on renal hemodynamics, water and sodium excretion, and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide, and vasopressin in pigs. Transplantation 58, 1153\u20131157 (1994).","journal-title":"Transplantation"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"e39229","DOI":"10.1371\/journal.pone.0039229","article-title":"Sirolimus induced phosphaturia is not caused by inhibition of renal apical sodium phosphate cotransporters","volume":"7","author":"Haller M","year":"2012","unstructured":"M Haller, et al., Sirolimus induced phosphaturia is not caused by inhibition of renal apical sodium phosphate cotransporters. PLoS ONE 7, e39229 (2012).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"154S","DOI":"10.1016\/S0041-1345(03)00224-0","article-title":"Tubular function in patients with hypokalemia induced by sirolimus after renal transplantation","volume":"35","author":"Morales JM","year":"2003","unstructured":"JM Morales, et al., Tubular function in patients with hypokalemia induced by sirolimus after renal transplantation. Transplant Proc 35, 154S\u2013156S (2003).","journal-title":"Transplant Proc"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1034\/j.1600-6143.2002.20507.x","article-title":"Sirolimus does not exhibit nephrotoxicity compared to cyclosporine in renal transplant recipients","volume":"2","author":"Morales JM","year":"2002","unstructured":"JM Morales, et al., Sirolimus does not exhibit nephrotoxicity compared to cyclosporine in renal transplant recipients. Am J Transplant; Sirolimus European Renal Transplant Study Group 2, 436\u2013442 (2002).","journal-title":"Am J Transplant"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/ndt\/gfq172","article-title":"Rapamycin-induced phosphaturia","volume":"25","author":"Kempe DS","year":"2010","unstructured":"DS Kempe, et al., Rapamycin-induced phosphaturia. Nephrol Dial Transplant 25, 2938\u20132944 (2010).","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/01.ASN.0000057542.86377.5A","article-title":"Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use","volume":"14","author":"Smith KD","year":"2003","unstructured":"KD Smith, et al., Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use. J Am Soc Nephrol 14, 1037\u20131045 (2003).","journal-title":"J Am Soc Nephrol"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.tp.0000225772.22757.5e","article-title":"Rapamycin delays but does not prevent recovery from acute renal failure: Role of acquired tubular resistance","volume":"82","author":"Lieberthal W","year":"2006","unstructured":"W Lieberthal, R Fuhro, C Andry, V Patel, JS Levine, Rapamycin delays but does not prevent recovery from acute renal failure: Role of acquired tubular resistance. Transplantation 82, 17\u201322 (2006).","journal-title":"Transplantation"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(12)61767-X","article-title":"Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial","volume":"381","author":"Bissler JJ","year":"2013","unstructured":"JJ Bissler, et al., Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial. Lancet 381, 817\u2013824 (2013).","journal-title":"Lancet"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1056\/NEJMoa066838","article-title":"Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma","volume":"356","author":"Hudes G","year":"2007","unstructured":"G Hudes, et al., Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med; Global ARCC Trial 356, 2271\u20132281 (2007).","journal-title":"N Engl J Med"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJMoa1109653","article-title":"Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer","volume":"366","author":"Baselga J","year":"2012","unstructured":"J Baselga, et al., Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 366, 520\u2013529 (2012).","journal-title":"N Engl J Med"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1097\/01.ASN.0000016444.90348.50","article-title":"Epithelial-specific Cre\/lox recombination in the developing kidney and genitourinary tract","volume":"13","author":"Shao X","year":"2002","unstructured":"X Shao, S Somlo, P Igarashi, Epithelial-specific Cre\/lox recombination in the developing kidney and genitourinary tract. J Am Soc Nephrol 13, 1837\u20131846 (2002).","journal-title":"J Am Soc Nephrol"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: Generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo W","year":"2009","unstructured":"W Luo, MS Friedman, K Shedden, KD Hankenson, PJ Woolf, GAGE: Generally applicable gene set enrichment for pathway analysis. BMC Bioinformatics 10, 161 (2009).","journal-title":"BMC Bioinformatics"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nature06322","article-title":"mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex","volume":"450","author":"Cunningham JT","year":"2007","unstructured":"JT Cunningham, et al., mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450, 736\u2013740 (2007).","journal-title":"Nature"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1073\/pnas.090091297","article-title":"Uncompensated polyuria in a mouse model of Bartter\u2019s syndrome","volume":"97","author":"Takahashi N","year":"2000","unstructured":"N Takahashi, et al., Uncompensated polyuria in a mouse model of Bartter\u2019s syndrome. Proc Natl Acad Sci USA 97, 5434\u20135439 (2000).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ando.2012.03.032","article-title":"Physiopathology and diagnosis of nephrogenic diabetes insipidus","volume":"73","author":"Devuyst O","year":"2012","unstructured":"O Devuyst, Physiopathology and diagnosis of nephrogenic diabetes insipidus. Ann Endocrinol (Paris) 73, 128\u2013129 (2012).","journal-title":"Ann Endocrinol (Paris)"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"27643","DOI":"10.1074\/jbc.M603536200","article-title":"The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity","volume":"281","author":"Schieke SM","year":"2006","unstructured":"SM Schieke, et al., The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem 281, 27643\u201327652 (2006).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.devcel.2006.10.007","article-title":"Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1","volume":"11","author":"Guertin DA","year":"2006","unstructured":"DA Guertin, et al., Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11, 859\u2013871 (2006).","journal-title":"Dev Cell"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm.3313","article-title":"AKT2 is essential to maintain podocyte viability and function during chronic kidney disease","volume":"19","author":"Canaud G","year":"2013","unstructured":"G Canaud, et al., AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nat Med 19, 1288\u20131296 (2013).","journal-title":"Nat Med"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI44774","article-title":"Role of mTOR in podocyte function and diabetic nephropathy in humans and mice","volume":"121","author":"G\u00f6del M","year":"2011","unstructured":"M G\u00f6del, et al., Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121, 2197\u20132209 (2011).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI37829","article-title":"Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models","volume":"119","author":"Brooks C","year":"2009","unstructured":"C Brooks, Q Wei, SG Cho, Z Dong, Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 119, 1275\u20131285 (2009).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nm.1865","article-title":"An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice","volume":"14","author":"Traykova-Brauch M","year":"2008","unstructured":"M Traykova-Brauch, et al., An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med 14, 979\u2013984 (2008).","journal-title":"Nat Med"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000348496","article-title":"Effects of everolimus on oxidative stress in kidney model of ischemia\/reperfusion injury","volume":"37","author":"Kezic A","year":"2013","unstructured":"A Kezic, F Thaiss, JU Becker, TY Tsui, M Bajcetic, Effects of everolimus on oxidative stress in kidney model of ischemia\/reperfusion injury. Am J Nephrol 37, 291\u2013301 (2013).","journal-title":"Am J Nephrol"},{"key":"e_1_3_4_37_2","unstructured":"Committee on Care and Use of Laboratory Animals (1985) Guide for the Care and Use of Laboratory Animals (Natl Inst Health Bethesda) DHHS Publ No (NIH) 85-23."},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cmet.2008.10.002","article-title":"Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy","volume":"8","author":"Bentzinger CF","year":"2008","unstructured":"CF Bentzinger, et al., Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8, 411\u2013424 (2008).","journal-title":"Cell Metab"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy","volume":"358","author":"Eremina V","year":"2008","unstructured":"V Eremina, et al., VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358, 1129\u20131136 (2008).","journal-title":"N Engl J Med"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000214439","article-title":"Responses to diuretic treatment in gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1","volume":"32","author":"Artunc F","year":"2009","unstructured":"F Artunc, et al., Responses to diuretic treatment in gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Kidney Blood Press Res 32, 119\u2013127 (2009).","journal-title":"Kidney Blood Press Res"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ygeno.2012.08.003","article-title":"A single-sample microarray normalization method to facilitate personalized-medicine workflows","volume":"100","author":"Piccolo SR","year":"2012","unstructured":"SR Piccolo, et al., A single-sample microarray normalization method to facilitate personalized-medicine workflows. Genomics 100, 337\u2013344 (2012).","journal-title":"Genomics"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"Dai M","year":"2005","unstructured":"M Dai, et al., Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res 33, e175 (2005).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0022-5347(17)52273-9","article-title":"An organ culture model for the study of metanephric development","volume":"129","author":"Avner ED","year":"1983","unstructured":"ED Avner, DB Villee, EE Schneeberger, WE Grupe, An organ culture model for the study of metanephric development. J Urol 129, 660\u2013664 (1983).","journal-title":"J Urol"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1242\/dev.02095","article-title":"Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa","volume":"132","author":"Gao X","year":"2005","unstructured":"X Gao, et al., Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development 132, 5437\u20135449 (2005).","journal-title":"Development"}],"updated-by":[{"DOI":"10.1073\/pnas.1522405112","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000}}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1402352111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T07:22:49Z","timestamp":1654586569000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1402352111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,23]]},"references-count":44,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2014,7,8]]}},"alternative-id":["10.1073\/pnas.1402352111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1402352111","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718465470.793497318","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,23]]},"assertion":[{"value":"2014-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}