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This element led to the identification of a new resistance gene and associated enzyme responsible for inactivating rifamycin antibiotics by phosphorylation. Cryptic orthologous genes are also found in pathogenic bacteria but remain susceptible to the drug. This study reveals a new antibiotic resistance protein family and the unexpected prevalence of a silent rifamycin resistome among pathogenic bacteria.<\/jats:p>","DOI":"10.1073\/pnas.1402358111","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T03:37:37Z","timestamp":1398742657000},"page":"7102-7107","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria"],"prefix":"10.1073","volume":"111","author":[{"given":"Peter","family":"Spanogiannopoulos","sequence":"first","affiliation":[{"name":"Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8S 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Waglechner","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8S 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalinka","family":"Koteva","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8S 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Michael G. 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