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They use the classical taste transduction cascade to detect potential hazardous compounds (bitter, umami, uropathogenic bacteria) and release acetylcholine in response. They lie next to sensory nerve fibers that carry acetylcholine receptors, and placing a bitter compound in the urethra enhances activity of the bladder detrusor muscle. Thus, monitoring of urethral content is linked to bladder control via a previously unrecognized cell type.<\/jats:p>","DOI":"10.1073\/pnas.1402436111","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T22:36:03Z","timestamp":1400538963000},"page":"8287-8292","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":165,"title":["Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes"],"prefix":"10.1073","volume":"111","author":[{"given":"Klaus","family":"Deckmann","sequence":"first","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Filipski","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Krasteva-Christ","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"},{"name":"German Center for Lung Research, 35392 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fronius","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Otago, 9016 Dunedin, New Zealand;"},{"name":"Institute of Animal Physiology, Justus-Liebig University, 35392 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Althaus","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology, Justus-Liebig University, 35392 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Rafiq","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liane","family":"Renno","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innokentij","family":"Jurastow","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wessels","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Wolff","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Justus-Liebig University, 35385 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Sch\u00fctz","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Philipps University, 35037 Marburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Weihe","sequence":"additional","affiliation":[{"name":"German Center for Lung Research, 35392 Giessen, Germany;"},{"name":"Institute of Anatomy and Cell Biology, Philipps University, 35037 Marburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Chubanov","sequence":"additional","affiliation":[{"name":"Walter-Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilian University, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gudermann","sequence":"additional","affiliation":[{"name":"German Center for Lung Research, 35392 Giessen, Germany;"},{"name":"Walter-Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilian University, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany; 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