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Apoptosis is reported to take place in wasting muscle in cancer cachexia, a debilitating syndrome associated with multiple types of cancer, although the mechanism remains elusive. This study shows that tumor-secreted microvesicles contain an elevated expression of miR-21 and induce myoblast apoptosis in cancer cachexia via a Toll-like receptor 7-c-Jun N-terminal kinase-dependent pathway.<\/jats:p>","DOI":"10.1073\/pnas.1402714111","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T21:34:20Z","timestamp":1394487260000},"page":"4525-4529","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":231,"title":["Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via\n                    <i>TLR7<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"Wei A.","family":"He","sequence":"first","affiliation":[{"name":"Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, and the Arthur G. 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