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These findings advance our understanding of the molecular mechanisms of PNI and define the specific cancer cell requirements necessary for PNI to occur. This work promotes the concept that a ligand and receptor both released by the microenvironment may cooperate together to facilitate cancer invasion. These findings highlight the key participatory role that the nerve microenvironment plays in enabling cancer perineural invasion.<\/jats:p>","DOI":"10.1073\/pnas.1402944111","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T03:37:37Z","timestamp":1398742657000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":129,"title":["GFR\u03b11 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling"],"prefix":"10.1073","volume":"111","author":[{"given":"Shuangba","family":"He","sequence":"first","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"},{"name":"Department of Otolaryngology, Anhui Provincial Hospital, Anhui Medical University, Anhui 230001, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Chernichenko","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Bakst","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mount Sinai Hospital, New York, NY 10029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Barajas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Deborde","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efsevia","family":"Vakiani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 20021; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Nanjing Tongren Hospital, Southeast University, Nanjing 211102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/000348948509400420","article-title":"Nerves and neurotropic carcinomas","volume":"94","author":"Batsakis JG","year":"1985","unstructured":"JG Batsakis, Nerves and neurotropic carcinomas. 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