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Mice genetically engineered to be resistant to this adductive inhibition had high blood pressure basally and their hydrolase activity was fully resistant to inhibition by nitro fatty acid supplied directly or generated via the Mediterranean diet. Similarly nitro fatty acid lowered blood pressure and abrogated cardiac hypertrophy in a hypertension model in wild-type mice, but was ineffective in mutant mice. Thus, protection from hypertension afforded by the Mediterranean diet is mediated by nitro-fatty acid-dependent inhibition of soluble epoxide hydrolase.<\/jats:p>","DOI":"10.1073\/pnas.1402965111","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T22:36:03Z","timestamp":1400538963000},"page":"8167-8172","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":96,"title":["Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase"],"prefix":"10.1073","volume":"111","author":[{"given":"Rebecca L.","family":"Charles","sequence":"first","affiliation":[{"name":"King\u2019s College London, Cardiovascular Division, British Heart Foundation Centre of Excellence, The Rayne Institute, St. Thomas\u2019 Hospital, London SE1 7EH, United 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