{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:43:53Z","timestamp":1789890233445,"version":"4.0.1"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>In eukaryotic cilia and flagella, outer arm dyneins (OADs) are bound to axonemal doublet microtubules every 24 nm; however, how this regular arrangement is produced remains unknown. To approach this problem, we studied the properties of the OAD-docking complex (ODA-DC), a three-subunit complex that functions as the OAD-docking site on the doublet. Using recombinant ODA-DC, we found that the ODA-DC has an \u223c24-nm-long ellipsoidal shape and cooperatively binds to the axoneme in an end-to-end manner. These and other results indicate that cooperative association of the ODA-DC underlies the periodic OAD arrangement at specific positions on the doublets. These findings provide insight into how the regular axonemal repeat structure is produced.<\/jats:p>","DOI":"10.1073\/pnas.1403101111","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T22:56:38Z","timestamp":1402959398000},"page":"9461-9466","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":55,"title":["Cooperative binding of the outer arm-docking complex underlies the regular arrangement of outer arm dynein in the axoneme"],"prefix":"10.1073","volume":"111","author":[{"given":"Mikito","family":"Owa","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Usukura","sequence":"additional","affiliation":[{"name":"EcoTopia Science Institute, Nagoya University, Chikusa, Nagoya 464-8602, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Arisaka","sequence":"additional","affiliation":[{"name":"Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8510, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B.","family":"Witman","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsu","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan;"},{"name":"Department of Life Sciences, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Chemical Resources Laboratory, Tokyo Institute of Technology, Yokohama 226-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.066308"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128618"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.02.072"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0169(1998)39:4<303::AID-CM5>3.0.CO;2-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.10004"},{"key":"e_1_3_3_6_2","first-page":"209","volume-title":"Dyneins: Structure, Biology and Disease","author":"King SM","year":"2011","unstructured":"SM King, Composition and assembly of axonemal dyneins. Dyneins: Structure, Biology and Disease, ed SM King (Elsevier, London), pp. 209\u2013243 (2011)."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.970310205"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.970280303"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1652"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.040705.141301"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2278"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.9.9.2337"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07471"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.126.3.737"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0169(1997)36:1<68::AID-CM6>3.0.CO;2-D"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.1015"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.6.2253"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.137.5.1069"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-04-0201"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-01-0057"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303064200"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0059CI"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.11.002"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-06-0461"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.05.058"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.3.902"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.970040506"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.11.5759"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.2.399"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)92989-3"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.2.371"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.03.028"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.4.835"},{"key":"e_1_3_3_34_2","volume-title":"The Chlamydomonas Sourcebook","author":"Harris EH","year":"1989","unstructured":"EH Harris The Chlamydomonas Sourcebook (Academic, San Diego, 1989)."},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.54.6.1665"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76713-0"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1403101111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:30:57Z","timestamp":1649806257000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1403101111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,16]]},"references-count":36,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1073\/pnas.1403101111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1403101111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,16]]},"assertion":[{"value":"2014-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}