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We clarified decades-long uncertainty about the timing and sequence of genomic alterations that underpinned the global epidemic. Analyses of this type are crucial for developing better strategies to predict and monitor strain emergence and epidemics, formulate effective protective public health maneuvers, and develop or modify vaccines.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1403138111","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T23:58:43Z","timestamp":1397519923000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":255,"title":["Evolutionary pathway to increased virulence and epidemic group A\n                    <i>Streptococcus<\/i>\n                    disease derived from 3,615 genome sequences"],"prefix":"10.1073","volume":"111","author":[{"given":"Waleed","family":"Nasser","sequence":"first","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030;"},{"name":"Houston Methodist Hospital, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Beres","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030;"},{"name":"Houston Methodist Hospital, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030;"},{"name":"Houston Methodist Hospital, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Dean","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030;"},{"name":"Houston Methodist Hospital, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey A.","family":"Rice","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030;"},{"name":"Houston Methodist Hospital, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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