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To achieve genome-wide hypothesis-free identification of genes and pathways associated with prefrontal\u2013hippocampal interactions, we combined gene set enrichment analysis with whole-genome genotyping and functional magnetic resonance imaging data from 269 healthy German volunteers. We found significant enrichment of the synapse organization and biogenesis gene set. This gene set included known schizophrenia risk genes, such as neural cell adhesion molecule (\n                    <jats:italic>NRCAM<\/jats:italic>\n                    ) and calcium channel, voltage-dependent, beta 2 subunit (\n                    <jats:italic>CACNB2<\/jats:italic>\n                    ), as well as genes with well-defined roles in neurodevelopmental and plasticity processes that are dysfunctional in schizophrenia and have mechanistic links to prefrontal\u2013hippocampal functional interactions. Our results demonstrate a readily generalizable approach that can be used to identify the neurogenetic basis of systems-level phenotypes. Moreover, our findings identify gene sets in which genetic variation may contribute to disease risk through altered prefrontal\u2013hippocampal functional interactions and suggest a link to both ongoing and developmental synaptic plasticity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1404082111","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T22:56:38Z","timestamp":1402959398000},"page":"9657-9662","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: Identification of gene ontologies linked to prefrontal\u2013hippocampal functional coupling in the human brain"],"prefix":"10.1073","volume":"111","author":[{"given":"Luanna","family":"Dixson","sequence":"first","affiliation":[{"name":"Departments of aPsychiatry and Psychotherapy 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