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Our results demonstrate dual, phase-specific release of AA and 15-hydroxyeicosatetraenoic (15-HETE) acid by GIVA cPLA\n                    <jats:sub>2<\/jats:sub>\n                    in primary and immortalized macrophages during a receptor-mediated program required for complete inflammatory commitment. These dual actions by GIVA cPLA\n                    <jats:sub>2<\/jats:sub>\n                    were necessary for biosynthesis of proresolving lipoxins, providing a unique, upstream example of an enzyme linked to both the initiation and resolution of inflammation. Further, our results demonstrate a single-cell mechanism of lipoxin synthesis that is more efficient than the established transcellular biosynthetic mechanisms, underscoring the importance of enzyme coupling and the possibility of proresolution therapies at the membrane level.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1404372111","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T23:39:11Z","timestamp":1408491551000},"page":"12746-12751","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":153,"title":["Phospholipase A\n                    <sub>2<\/sub>\n                    regulates eicosanoid class switching during inflammasome activation"],"prefix":"10.1073","volume":"111","author":[{"given":"Paul C.","family":"Norris","sequence":"first","affiliation":[{"name":"Departments of aChemistry\/Biochemistry and Pharmacology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gosselin","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Reichart","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Glass","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Departments of aChemistry\/Biochemistry and Pharmacology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.3877"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4049\/jimmunol.159.3.1451","article-title":"Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages","volume":"159","author":"Ferrari D","year":"1997","unstructured":"D Ferrari, et al., Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. 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