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In this paper, we show that volatile general anesthetics cause large changes in electron spin in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    fruit flies and that the spin responses are different in anesthesia-resistant mutants. We propose that anesthetics perturb electron currents in cells and describe electronic structure calculations on anesthetic\u2013protein interactions that are consistent with this mechanism and account for hitherto unexplained features of general anesthetic pharmacology.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1404387111","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T02:59:19Z","timestamp":1407812359000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["Electron spin changes during general anesthesia in\n                    <i>Drosophila<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"Luca","family":"Turin","sequence":"first","affiliation":[{"name":"Division of Neuroscience, Biomedical Sciences Research Centre Alexander Fleming, 16672 Vari, Greece; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimios M. 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