{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:58:34Z","timestamp":1791349114352,"version":"4.3.1"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"32","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,8,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Follicular helper T (T\n                    <jats:sub>FH<\/jats:sub>\n                    ) cells have emerged as the key cell type required for the formation of germinal centers and subsequent long-lasting antibody responses. It has been demonstrated that T\n                    <jats:sub>FH<\/jats:sub>\n                    cells enter the memory pool. However, it is unclear how the generation, survival, or activation of those T\n                    <jats:sub>FH<\/jats:sub>\n                    memory cells is regulated. Here we show that B-cell lymphoma 6 (Bcl6), a master regulator of T\n                    <jats:sub>FH<\/jats:sub>\n                    generation, is required for maintenance of T\n                    <jats:sub>FH<\/jats:sub>\n                    memory cells and subsequent humoral memory. In these recall responses, antigen-specific memory B cells majorly contribute to the quick induction of Bcl6 in T\n                    <jats:sub>FH<\/jats:sub>\n                    memory cells. Our results reinforce the importance of cognate interaction between memory T\n                    <jats:sub>FH<\/jats:sub>\n                    and memory B cells and give important implications for development of better vaccines.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1404671111","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T02:39:50Z","timestamp":1406601590000},"page":"11792-11797","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells"],"prefix":"10.1073","volume":"111","author":[{"given":"Wataru","family":"Ise","sequence":"first","affiliation":[{"name":"Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Kometani","sequence":"additional","affiliation":[{"name":"Laboratory for Lymphocyte Differentiation,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kubo","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Regulation, and"},{"name":"Division of Molecular Pathology, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda-shi, Chiba 278-0022, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaharu","family":"Okada","sequence":"additional","affiliation":[{"name":"Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan;"},{"name":"Laboratory for Lymphocyte Differentiation,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101400"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175870"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176676"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.07.002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.023"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.015"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100853"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07345"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101393"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.007"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120219"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2261"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242540"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.016"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.009"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.025"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.002"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301284"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005443107"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.020"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm007"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni802"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202963"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.014"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00939.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3128"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062571"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1814"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201730"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80523-3"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00365-5"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni776"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120127"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1404671111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:42:52Z","timestamp":1649803372000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1404671111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,28]]},"references-count":34,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2014,8,12]]}},"alternative-id":["10.1073\/pnas.1404671111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1404671111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,28]]},"assertion":[{"value":"2014-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}