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Altered mRNA expression was in some cases strongly correlated with the presence of G4 motifs, which may form G-quadruplex targets that are bound by BLM. Further analysis of the genetic networks we identified may elucidate mechanisms responsible for Bloom syndrome disease pathogenesis and ways to ameliorate or prevent disease in affected individuals.<\/jats:p>","DOI":"10.1073\/pnas.1404807111","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T04:39:14Z","timestamp":1403584754000},"page":"9905-9910","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":122,"title":["Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs"],"prefix":"10.1073","volume":"111","author":[{"given":"Giang Huong","family":"Nguyen","sequence":"first","affiliation":[{"name":"Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Department of Medical Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Tang","sequence":"additional","affiliation":[{"name":"Departments of cPathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Robles","sequence":"additional","affiliation":[{"name":"Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Beyer","sequence":"additional","affiliation":[{"name":"Center for Ecogenetics and Environmental Health, University of Washington, Seattle, WA 98105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Immunology and Biochemistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Schetter","sequence":"additional","affiliation":[{"name":"Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Kumamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Department of Organ Regulatory Surgery, Fukushima Medical University, Fukushima City 960-1295, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Hickson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom;"},{"name":"Department of Cellular and Molecular Medicine, Nordea Center for Healthy Aging, University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Maizels","sequence":"additional","affiliation":[{"name":"Immunology and Biochemistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Raymond J.","family":"Monnat","sequence":"additional","affiliation":[{"name":"Departments of cPathology,"},{"name":"Genome Sciences, University of Washington, Seattle, WA 98195;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis C.","family":"Harris","sequence":"additional","affiliation":[{"name":"Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,6,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0092-8674(95)90105-1","article-title":"The Bloom\u2019s syndrome gene product is homologous to RecQ helicases","volume":"83","author":"Ellis NA","year":"1995","unstructured":"NA Ellis, et al., The Bloom\u2019s syndrome gene product is homologous to RecQ helicases. 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