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Surprisingly, we observed strong conservation of the sequence of most vertically inherited prophages, including selection for genes encoding phage-specific functions. These results suggest pervasive domestication of parasites by the bacterial hosts. Because prophages account for a large fraction of bacterial genomes, phage domestication may drive bacterial adaptation.<\/jats:p>","DOI":"10.1073\/pnas.1405336111","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T02:19:13Z","timestamp":1407205153000},"page":"12127-12132","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":405,"title":["Pervasive domestication of defective prophages by bacteria"],"prefix":"10.1073","volume":"111","author":[{"given":"Louis-Marie","family":"Bobay","sequence":"first","affiliation":[{"name":"Microbial Evolutionary Genomics, Institut Pasteur, 75724 Paris, France;"},{"name":"CNRS, UMR 3525, 75724 Paris, France; and"},{"name":"Sorbonne Universit\u00e9s, UPMC, Universit\u00e9 Paris 6, IFD, 75252 Paris Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Touchon","sequence":"additional","affiliation":[{"name":"Microbial Evolutionary Genomics, Institut Pasteur, 75724 Paris, France;"},{"name":"CNRS, UMR 3525, 75724 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo P. 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