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In the absence of NEDD9, failure to activate Aurora-A kinase causes multiple abnormalities in cilia, intensifying the effect of genetic deficiency of mutations in the polycystic kidney disease (PKD) 1 gene, the most common cause of PKD. As important implications, clinical inhibitors of Aurora-A also intensified ADPKD induced by mutation of\n                    <jats:italic>PKD1<\/jats:italic>\n                    , suggesting caution in use of these agents, whereas recently reported polymorphisms in Nedd9 may contribute to the genetic heterogeneity of ADPKD presentation in affected families.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1405362111","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T23:39:11Z","timestamp":1408491551000},"page":"12859-12864","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["<i>Nedd9<\/i>\n                    restrains renal cystogenesis in\n                    <i>Pkd1<\/i>\n                    <sup>\n                      <i>\u2212\/\u2212<\/i>\n                    <\/sup>\n                    mice"],"prefix":"10.1073","volume":"111","author":[{"given":"Anna 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