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Borrelidin, a natural compound that inhibits threonyl-tRNA synthetase, has long been studied for its antibacterial and antiparasitic properties, but undesirable toxic effects prevented its further clinical development. Here we present a group of borrelidin derivatives that retain their ability to inhibit\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    threonyl-tRNA synthetase but not its human homolog. Furthermore, we demonstrate, for the first time to our knowledge, that these compounds are capable of effectively clearing a\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection in animals, curing malaria with a potency equivalent to reference drugs such as chloroquine.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1405994111","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:58:08Z","timestamp":1418086688000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":82,"title":["Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo"],"prefix":"10.1073","volume":"111","author":[{"given":"Eva Maria","family":"Novoa","sequence":"first","affiliation":[{"name":"Institute for Research in Biomedicine, 08028 Barcelona, Catalonia, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Camacho","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine, 08028 Barcelona, Catalonia, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tor","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine, 08028 Barcelona, Catalonia, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrie","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Biotica Technology Ltd., Cambridge CB21 6AD, United Kingdom;"},{"name":"Isomerase Therapeutics Ltd., Cambridge CB10 1XL, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Moss","sequence":"additional","affiliation":[{"name":"Biotica Technology Ltd., Cambridge CB21 6AD, United Kingdom;"},{"name":"Isomerase Therapeutics Ltd., Cambridge CB10 1XL, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mar\u00edn-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology IV and Research Institute Hospital 12 de Octubre, Complutense University of Madrid, 28040 Madrid, Spain;"},{"name":"Health Sciences School, Medical Immunology Unit, Rey Juan Carlos University, 28922 Alcorc\u00f3n (Madrid), Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel G.","family":"Azc\u00e1rate","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology IV and Research Institute Hospital 12 de Octubre, Complutense University of Madrid, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Bautista","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology IV and Research Institute Hospital 12 de Octubre, Complutense University of Madrid, 28040 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Mirando","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Francklyn","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f2nia","family":"Varon","sequence":"additional","affiliation":[{"name":"Combinatorial Chemistry Unit, University of Barcelona, 08028 Barcelona, Catalonia, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Royo","sequence":"additional","affiliation":[{"name":"Combinatorial Chemistry Unit, University of Barcelona, 08028 Barcelona, Catalonia, Spain;"},{"name":"Bioengineering Biomaterial and Nanomedicine Networking Center, 08028 Barcelona, Catalonia, Spain; 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